AskDefine | Define barbital

Dictionary Definition

barbital n : a barbiturate used as a hypnotic [syn: veronal, barbitone, diethylbarbituric acid, diethylmalonylurea]

Extensive Definition

Barbital (marketed under the brand name Veronal), also called barbitone, was the first commercially marketed barbiturate. It was used as a sleeping aid (hypnotic) from 1903 until the mid-1950s. The chemical names for barbital are diethylmalonyl urea or diethylbarbituric acid. Its chemical formula is (C2H5)2C~CO NH]ICO (sodium 5,5-diethyl barbiturate). Veronal was prepared by condensing diethylmalonic ester with urea in the presence of sodium ethylate, or by adding ethyl iodide to the silver salt of malonylurea. The result was an odorless, slightly bitter, white crystalline powder.

Synthesis

Barbital was first synthesized in 1902 by German chemists Emil Fischer and Joseph von Mering. They published their discovery in 1903 and it was marketed in 1904 by the Bayer company as “Veronal”. A soluble salt of barbital was marketed by the Schering company as “Medinal.” It was dispensed for “insomnia induced by nervous excitability”. http://www.henriettesherbal.com/eclectic/ellingwood/veronal.html It was provided in either capsules or cachets. The therapeutic dose was ten to fifteen grains (0.65-0.97 grams). 3.5 to 4.4 grams is the deadly dose but sleep has also been prolonged up to ten days with recovery.

Pharmacology

Veronal was considered to be a great improvement over the existing hypnotics. Its taste was slightly bitter, but an improvement over the strong, unpleasant taste of the commonly used bromides. It had few side effects. Its therapeutic dose was far below the toxic dose. However, prolonged usage resulted in tolerance to the drug, requiring higher doses to reach the desired effect. Fatal overdoses of this slow acting hypnotic were not uncommon.

References

  • Fischer, Emil and Joseph von Mering, “Ueber eine neue Klasse von Schlafmitteln”, Therap Gegenw 44:97-101, 1903.
  • "Veronal", in Finley, Ellingwood, M.D. ''The American Materia Medica, Therapeutics and Pharmacognosy", 1919. http://www.henriettesherbal.com/eclectic/ellingwood/veronal.html, accessed 07 Nov 2005.
  • "Emma Zunz" by Jorge Luis Borges (short story)
barbital in German: Barbital
barbital in Spanish: Barbital
barbital in Galician: Barbital
barbital in Italian: Barbital
barbital in Dutch: Barbital
barbital in Japanese: バルビタール
barbital in Norwegian: Barbital
barbital in Polish: Barbital
barbital in Portuguese: Veronal
barbital in Russian: Барбитал
barbital in Slovenian: Barbital
barbital in Swedish: Barbital
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